Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet
Fig 5
Pyruvate tolerance test (PTT) in HFD-fed WT and AnxA6-KO mice.
(A-B) HFD-fed and chow fed (C) WT and AnxA6-KO (AnxA6-/-, A6-/-) mice were starved for 4 h prior to intraperitoneal pyruvate administration (2 g/kg body weight). Blood glucose levels were monitored for 0–180 min (mean ± SEM; n = 19 at 0 min, n = 15 at 15, 30, 60 min, n = 10 at 90 min, n = 5 at 120, 180 min); (B-C) Area under the curve (AUC, mean ± SEM) of glucose levels during the PTT of (B) HFD-fed and (C) chow-fed WT and AnxA6-KO mice. (D) Plasma insulin levels of HFD-fed WT and AnxA6-KO mice during the PTT at t = 0, 60 and 120 min following pyruvate administration (mean ± SEM; n = 4–5 for each time point). * P < 0.05, ** P < 0.01; * P <0.05 (Student’s T-test).