High-fat diet suppresses the positive effect of creatine supplementation on skeletal muscle function by reducing protein expression of IGF-PI3K-AKT-mTOR pathway
Fig 5
Comparison of the CrM supplementation effect on muscle performance between SD-T rats (blue-triangle) and HF-T rats (red-circle).
(A) Maximal carrying load (g). (B) Carrying load normalized to body weight (g/g). (C) Total isotonic contraction (g). (D) Total isotonic contraction normalized to body weight (g/g). (E) Work (KJ). (F), Work normalized to body weight (KJ/g). n = 5. * p< 0.05; ** p< 0.01.