Genistein induces macrophage polarization and systemic cytokine to ameliorate experimental colitis
Fig 3
Genistein decreases the percentage and number of M1 macrophages.
Genistein reduces the number and percentage of M1 macrophages in mice with acute colitis. Splenic, MLNs, and LP lymphocytes were isolated from the two groups of mice. Changes in the mean percentage of CD11b + CD11c (M1 phenotype) expression were compared between groups. Numbers in the upper right quadrant of the charts indicate the total percentage of M1 macrophages phenotypes. Data represent the total frequency of cells ± SEM from three independent experiments. Asterisks (✶) indicate statistically significant differences (p < 0.01) between vehicle-and genistein-treated groups.