Oxaliplatin-induced changes in microbiota, TLR4+ cells and enhanced HMGB1 expression in the murine colon
Fig 5
Effects of oxaliplatin treatment on the composition of intestinal microbiota.
Fecal microbiota Chao richness estimate, Simpson diversity estimate and evenness following oxaliplatin treatment were analysed using 16S rRNA sequencing. Oxaliplatin treatment did not cause any significant changes to the number of OTUs (A), Chao richness estimate (B), Simpson diversity estimate (C) or PCoA unweighted UniFrac distance percentages (D). Oxaliplatin treatment did not cause any significant changes to five dominant phyla groups identified in the fecal microbiota: Bacteroidetes (E), Deferribacteres (F), Firmicutes (G), Proteobacteria (H) and Tenericutes (I). Oxaliplatin treatment caused a significant reduction in Parabacteroides (J) and Prevotella1 (K) species, and a significant increase in Prevotella2 (L) and Odoribacter species (M). *P<0.05; **P<0.01; ****P<0.0001; n = 10/group.