Attention and working memory deficits in a perinatal nicotine exposure mouse model
Fig 2
Perinatal nicotine exposure and anxiety-like phenotype in elevated plus maze (EPM).
The percentage of time spent in the open versus closed arms (A) and the number of entries into open arms (B) of the EPM were analyzed. Neither measure showed significant difference in male or female mice from the nicotine+saccharin (N + S), saccharin alone (S) and plain drinking water (W) groups. [Mean ± SEM % time spent in open arms: Male: W = 26.44 ± 4.34; S = 23.89 ± 2.88; N + S = 23.56 ± 2.56; Female: W = 17.65 ± 3.88; S = 19.05 ± 23.84; N + S = 21.53 ± 3.64. Mean ± SEM number of entries into open arms: Male: W = 9.67 ± 1.21; S = 9.33 ± 1.17; N + S = 9.5 ± 1.16; Female: W = 8.40 ± 1.32; S = 8.20 ± 1.33; N + S = 8.00 ± 1.20].