Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia
Fig 1
Differential DNA methylation patterns according to case-control status and maternal MTR rs12759827 genotype.
(A) Log ratio of methylation density comparing cases to controls across all genomic locations. Horizontal black lines represent the log ratio of mean methylation density in cases compared to controls. (B) Hierarchical clustering demonstrates differential promoter methylation between controls (green) and CIMP- cases (pink) compared to CIMP+ cases (purple).