Complex interactions in a novel SCN5A compound mutation associated with long QT and Brugada syndrome: Implications for Na+ channel blocking pharmacotherapy for de novo conduction disease
Fig 2
Varying atrial activation in sinus rhythm.
A. Surface ECG and intracardiac electrograms showing varying P wave morphology and CS activation during sinus rhythm without changing heart rate. Note CS activation is distal to proximal on the first two beats, but then reverses by the fourth beat. B. Surface ECG and intracardiac electrograms showing varying P wave morphology and right atrial activation during sinus rhythm without a change in heart rate. Note the difference in high right atrial to His bundle activation time between the first and second beats. Abbreviations are the same as in Fig 1. CS indicates bipolar electrograms recorded from the proximal CS (CS 9–10) to distal CS (CS 1–2).