CD39 is upregulated during activation of mouse and human T cells and attenuates the immune response to Listeria monocytogenes
Fig 7
Acquired immune response of CD39-/- mice against L. monocytogenes.
Wildtype and CD39-/- mice were i.v. infected with 5×103 Lm. (A) Bacterial burden in spleens was determined at d7 post infection. Combined results for five individually analyzed mice and the median are shown. cfu, colony forming units. Mann Whitney test, ns p>0.05. (B) Wildtype and CD39-/- mice were i.v. infected with 1×105 LmOVA. On day 9 post infection, CD8+ T cells were analyzed with OVA257-264-dextramers. Representative dot plots and frequencies of dextramer+ cells among CD8+ T cells. Bars give the mean ± SEM of seven individually analyzed mice. Combined data of two experiments. Unpaired t test, *** p<0.001.