Blood-based cerebral biomarkers in preeclampsia: Plasma concentrations of NfL, tau, S100B and NSE during pregnancy in women who later develop preeclampsia - A nested case control study
Fig 3
Receiver Operating Characteristic (ROC) curves using S100B, Neuron Specific Enolase (NSE), Nerofilament Light chain (NfL) and tau combined for determining preeclampsia at specific gestational weeks.
a) 10, Area Under the Curve (AUC) = 0.67 (0.47–0.88), p = 0.103, 11 cases and 26 controls. AUC for NfL 0.33 (0.00–0.67), for tau 0.24 (0.00–0.58), for S100B 0.71 (0.39–1.00) and for NSE 0.24 (0.00–0.54). b) 25, AUC = 0.77 (0.61–0.93), p<0.05, 7 cases, 29 controls. AUC for NfL 0.29 (0.00–0.61), for tau 0.38 (0.00–0.78), for S100B 0.38 /0.02–0.74) and for NSE 0.48 (0.12–0.84). c) 28, AUC = 0.75 (0.56–0.95), p<0.05, 7 cases, 27 controls. AUC for NfL 0.29 (0.00–0.64), for tau 0.05 (0.00–0.18), for S100B 0.45 (0.06–0.85) and for NSE 0.43 (0.05–0.81). d) 33, AUC = 0.89 (0.73–1.00), p<0.01, 6 cases, 28 controls. AUC for NfL 0.62 (0.17–1.00), for tau 0.57 (0.19–0.95), for S100B 0.95 (0.82–1.00) and for NSE 0.71 (0.37–1.00). e) 37, AUC = 0.83 (0.66–1.00), p<0.01, 8 cases, 24 controls. AUC for NfL 0.71 (0.24–1.00), for tau 0.31 (0.00–0.65), for S100B 0.69 (0.31–1.00) and for NSE 0.48 (0.06–0.89).