CD44-mediated hyaluronan binding marks proliferating hematopoietic progenitor cells and promotes bone marrow engraftment
Fig 6
HA binding BMC confer a competitive advantage in BM progenitor reconstitution.
(A) Gating strategies for Lineage- BM, LSK, and CD150. (B-C) Percentage of WT-CD44 and GOF-CD44 (B) or LOF-CD44 cells (C) within the donor-derived BM lineage-, LSK, CD150+ LSK and CD150- LSK populations. Mean +/- SD from at least six biological replicates of two independent experiments. *p<0.05, ***p<0.001 calculated by Student’s t-test.