TGF-β1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels
Fig 8
Schematic depicting the mechanism of vascular differentiation and network formation by encapsulated hCDC.
Presentation of heparin-sequestered TGF-β1 to the TGF-βR2 and the CD105 co-receptor activates the ALK 1 and SMAD 1/5 pathways, resulting in increased angiogenic activity of encapsulated hCDC.