Comparison of neuroprotective efficacy of poly-arginine R18 and R18D (D-enantiomer) peptides following permanent middle cerebral artery occlusion in the Wistar rat and in vitro toxicity studies
Fig 7
Cell viability and cell death in HEK293 embryonic kidney cell cultures following exposure to different concentrations of R18 or R18D peptide for either 10 minutes or 24 hours as measured by MTS and LDH assays.
Peptide concentration in μM. Cell viability was measured 24-hours after the addition of peptide. A, B, C D: R18 and E, F, G, H: R18D. *p < 0.05 when compared to control [Cont = 100% cell viability (MTS assay) or 0% cell death (LDH assay)]. SDS = wells treated with SDS [SDS = 0% cell viability (MTS assay) or 100% cell death (LDH assay)]. Values are means ± SE; n = 4.