Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment
Fig 3
Model of cell cycle regulators and apoptosis modulators that are associated with impaired p53 (TP53) function in GIST.
Constitutive activated KIT or PDGFRA promotes proliferation and can be inhibited by imatinib. Impaired p53 function leads as well to a higher proliferation and inhibits apoptosis by modulation of cell cycle regulators. The analyzed proteins are displayed as circles with a bold boarder. Filled green circles indicate that this protein is associated with a favorable recurrence free survival in our study, filled red circles indicate that these regulators are associated with an unfavorable recurrence free survival.