Molecular epidemiology of tuberculosis in Tasmania and genomic characterisation of its first known multi-drug resistant case
Table 2
Mutations detected in the genome of the TASMDR1 isolate that confer resistance to anti-tubercular drugs.
Six mutations that have been associated with anti-tubercular drug resistance were identified. The mutations listed in the rpoB, katG, pncA, and embB genes were classified as high confidence SNPs with respect to resistance to rifampicin, isoniazid, pyrazinamide and ethambutol, respectively, by the PhyResSE database [12]. In addition, an A/C substitution was detected at position 514 of the 16S rRNA gene, rrs (MTB000019) that is associated with streptomycin resistance [33, 34].