Hepcidin deficiency and iron deficiency do not alter tuberculosis susceptibility in a murine M.tb infection model
Fig 5
Characterisation of more severe iron deficiency in younger mice.
Female 4–5 week old mice were fed an iron deficient (2–6ppm iron) or control (200ppm iron) diet for a total of 6 or 10 weeks. Animals were bled via cardiac puncture under terminal anaesthesia and liver and spleen were removed for quantification of tissue iron. Haematological parameters are shown in panels A-F, and liver and spleen non-heme iron content shown in G-H, respectively. Mann-Whitney tests were performed to compare groups where *, **, *** and **** indicate p = <0.05, p = <0.01, p = <0.001 and p = <0.0001, respectively. N = 6 per group.