Inferring hidden causal relations between pathway members using reduced Google matrix of directed biological networks
Fig 4
Several examples of network topologies, illustrating emergence of “creative elements”.
Here creative elements are defined as proteins whose PageRank or CheiRank can not be simply explained by the number of incoming or outgoing connections correspondingly. A and B) The size of the node is proportional to its PageRank value. C) The size of the protein is proportional to its CheiRank value. The color of the proteins in all three panels reflects the ratio between the number of incoming and outgoing edges. If the color is greenish then the protein is “importer” receiving more incoming regulations than having out-going edges. The reddish proteins are “exporters” regulating more proteins downstream than the number of incoming regulations.