Running wheel exercise reduces α-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease
Fig 6
Exercise increased α-synuclein concentration in blood plasma in 15-month old Y39C transgenic mouse.
Mouse blood plasma samples were processed by Western blot analysis using antibodies to LB509 (A) and Syn-1 (B). Both monomer and dimer α-synucleins were found in mouse plasma. Sample images are shown for each Western blot. (C, D) Quantitative α-synuclein plasma levels are shown for each group after being normalized to mouse serum albumin. With both LB509 (A) and Syn-1 (B) antibodies, there were significant increases in α-synuclein monomer, dimer and total (monomer plus dimer) fractions in Exercise versus Non-Exercise mouse plasma (n = 7, t-test, *p<0.05).