Short telomere length in IPF lung associates with fibrotic lesions and predicts survival
Fig 7
(A) FISH-TL on lung biopsy; Kaplan-Meier curve of 15 IPF patients showing a median survival of 60 months for patients with AT2 cell FISH-TL in non-fibrotic areas above median TL (solid line) and a median survival of 26 months for patients with AT2 cell TL below median TL (dotted line). The difference in median survival is 34 months (p = 0.353, Mantel-Cox). (B) MMqPCR on lung biopsy; Kaplan-Meier curve of 34 IPF patients showing a median survival of 63 months for IPF patients with a lung biopsy MMqPCR T/S ratio above the median (solid line) and a median survival of 22 months for patients with a lung biopsy MMqPCR T/S ratio below the median T/S (dotted line). The significant difference in median survival is 41 months (p = 0.003, Mantel-Cox). Deceased n = 27, lung transplantation n = 4, still alive n = 3.