Conjugation of nitrated acetaminophen to Der p1 amplifies peripheral blood monocyte response to Der p1
Fig 1
A. Structural simularity of 3-nitro-tyrosine and 3-nitro-acetaminophen (NAP) with 2,4-dinitrophenol, a well-known hapten. Acetaminophen shown for reference. B. Depiction of acetaminophen nitration reaction. C. High Performance Liquid Chromatography (HPLC) elution profile of NAP. Synthesized NAP was purified by HPLC, arrow denotes the NAP peak that is seen at elution time of 8 minutes. Figure is representative of results of multiple HPLC elutions and representative of similar profiles obtained at different pH.