Increased lipid availability for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation in healthy subjects
Fig 1
Effect of chronic (3 day) physiologic increase in plasma FFA concentration on insulin sensitivity parameters.
a: insulin-stimulated total body glucose disposal (TGD) and b: suppression of endogenous glucose production (EGP) during the euglycemic insulin clamp. n = 9, *p<0.05. c: Plasma insulin concentration following an overnight fast and during the two-step hyperglycemic clamp (+125 and +300 mg/dL) with arginine. n = 9, *p<0.05.