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Spatio-temporal dynamics of multimodal EEG-fNIRS signals in the loss and recovery of consciousness under sedation using midazolam and propofol

Fig 8

Grand-averaged time-courses of reaction curves for auditory stimuli (top layer) and group-level phase difference in the time domain with 5 × 5 fronto-parietal paired channels and two frequency ranges (theta and upper alpha) (bottom layer) for (A) midazolam and (B) propofol.

For group-level phase difference, the x-axis indicates the time intervals of the loss and recovery of consciousness during the two stages, and the y-axis was calculated with a time-series of instantaneous phase differences between all pair-wise combinations of fronto-parietal channels to show the phase relationship between channels [51, 52].

Fig 8

doi: https://doi.org/10.1371/journal.pone.0187743.g008