Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers
Fig 6
The mRNA expression of IQGAP2 and IQGAP3 in brain cancer subtypes and their correlation with survival of the patients.
(A) and (B): IQGAP2 mRNA expression in Oncomine and TCGA database, respectively in different brain cancer subtypes, represented as box whisker plots (C): IQGAP3 mRNA expression from TCGA database in different brain cancer subtypes represented as box-whisker plots. X-axis of the plot represents normal vs. cancer group; Y-axis represents mRNA expression in log2 median/mean centred intensity. Line in the middle represents the median value. Differences in mean, were examined statistically by two-tailed student’s t-test. (D) and (E): SurvExpress database showing overall patient survival (OS) in brain cancer with IQGAP2 and IQGAP3 expression, respectively. Figs (Da) and (Ea) showing Kaplan Meier plot of OS of gastric brain cancer patients with IQGAP2 and IQGAP3 expression respectively. Here at the top, p-value and 95% CI have been shown with selected data. Survival risk curves are shown for each group; low and high risk groups are shown in green and red colors respectively. The X-axis represents the time (days) to event. The number of samples not presenting the event at the matching time have been shown in rows with corresponding color. Figs (Db) and (Eb), Box plot of IQGAP2 and IQGAP3 by risk groups. The gene expression of each gene is plotted along risk groups obtained in the analysis. The X-axis shows each gene and a p-value of the expression difference between risk groups. The p-value is obtained from a t-test for two risk groups. Expression levels have been shown in the Y-axis.