Intrapancreatic injection of human bone marrow-derived mesenchymal stem/stromal cells alleviates hyperglycemia and modulates the macrophage state in streptozotocin-induced type 1 diabetic mice
Fig 1
Effects of hBMMSC injection on blood glucose and body weight of STZ-induced diabetic mice.
Mice were injected intravenously (A, C) or intrapancreatically (B, D) with hBMMSCs or the vehicle on day 7 after STZ treatment, and their blood glucose (A, B) and body weight (C, D) were monitored until day 28. Mice were intrapancreatically injected with hBMMSCs, HDFs, or the vehicle on day 7 after STZ treatment, and their blood glucose concentration (E) and body weight (F) were monitored until day 28. Data are expressed as the mean ± SEM. *p < 0.05, **p < 0.01 (vs vehicle injection); #p < 0.05 (vs HDF injection) (Tukey post-hoc test).