Impact of age and pre-existing influenza immune responses in humans receiving split inactivated influenza vaccine on the induction of the breadth of antibodies to influenza A strains
Fig 1
The box-and-whisker plots show the lower (Q1) and upper (Q4) quartile representing the IgG endpoint dilution titer for anti-HA antibodies. The diagram also shows the geometric mean titer (GMT) for day 0 and day 21 post-vaccination for each age group. The n value per age group is listed on the x-axis. (A) Serum samples were tested (A) 2014 season against rHA for the H1N1 component of the vaccine, A/California/07/2009 (CA/09). (B) 2015 season against rHA for the H1N1 component of the vaccine, A/California/07/2009 (CA/09). (C) 2014 season against rHA for the H3N2 component of the vaccine, A/Texas/50/2012 (TX/12). (D) 2014 season against rHA for the H3N2 component of the vaccine, A/Switzerland/9715293/2013 (Switz/13). *p≤0.05; *p≤0.01; *p≤0.001; *p≤0.0001.