Modeling of annexin A2—Membrane interactions by molecular dynamics simulations
Fig 8
Snapshots of the O6 systems at 50, 150 and 400 ns.
The AnxA2 repeats are shown in four different colors as in the previous figures. The Ca2+ ions are shown as red spheres, POPS lipids are shown in cyan and other lipids are shown transparent white. The single Ca2+ ion bound to AnxA2 at the initial times interacts with residues Glu125 and Asp251 (colored in yellow). Six lysine residues, i.e. Lys49, Lys81, Lys88, Lys279, Lys281 and Lys286, are highlighted in the middle row. The bottom plot shows the temporal total interaction of Lys49/81/88 as well as the interactions of individual Lys279, Lys 281 and Lys286 residues with the POPS lipids.