Role of the P2 residue of human alpha 1-antitrypsin in determining target protease specificity
Fig 5
A1AT-PPE interaction and surface charge display of PPE and HNE.
(a) Structural model of P357D and PPE based on the structure of A1AT-PPE (PDB ID: 2D26). Interaction between aspartate 357 of P357D and serine 195 of PPE is shown. (b) Surface charge display of PPE. (c) Surface charge display of HNE. Negative charges are shown in red and positive charges in blue.