Characterization of the microDNA through the response to chemotherapeutics in lymphoblastoid cell lines
Fig 1
MicroDNA are significantly enriched in coding and active genomic regions.
Fold enrichment is calculated as the ratio of the observed by expected number. Expected numbers were computed by generating 1000 random new positions with lengths corresponding to those of identified microDNAs and outputting the median. The dotted line shows a hypothetical situation where expected number would be equal to the observed number. Top: Methotrexate (MTX). Bottom: Asparaginase (ASP). Statistical significance was assessed using Fisher's Exact test (S3 Table).