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Evaluation of the adaptogenic potential exerted by ginsenosides Rb1 and Rg1 against oxidative stress-mediated neurotoxicity in an in vitro neuronal model

Fig 4

Effects of ginsenosides Rb1 and Rg1 on apoptosis-related factors.

(A) Caspase-3 activity and (B) protein expression, (C) Bax expression, (D) Bcl-2 expression and (D) cytosolic cytochrome C. Cells were pre-treated with ginsenosides (optimal doses, 24 h) and then exposed to rotenone (50 μM, 24 h). Data are expressed in percentage relative to control cells (100% of enzyme activity and expression). Means ± SD, * p < 0.05 Vs control, # p < 0.05 Vs H2O2.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0182933.g004