Optical sensing of anticoagulation status: Towards point-of-care coagulation testing
Fig 5
Effect of argatroban on LSR and TEG coagulation parameters.
Kaolin-activated swine blood spiked with 0 (control), 3.8, 5.7, 7.6, 15.2 μM argatroban was measured for 20–50 minutes and blood coagulation parameters including the clotting time (R+K), the clot progression (angle) and the maximum amplitude (MA) were extracted for each concentration (A-C). Correlation between LSR and TEG was evaluated using linear regression analysis (D-F). Each data point represents the mean of three replications ± SD (histograms) or standard error of the mean, SEM (linear regression). Values were compared between control samples (without treatment) and argatroban treated samples using ANOVA followed by the Tukey’s method for multiple comparisons post-tests. * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001.