Distinct age and differentiation-state dependent metabolic profiles of oligodendrocytes under optimal and stress conditions
Fig 5
Differential respiration profiles in metabolic stress conditions in post natal newly differentiated OLs and OPCs.
(A) NG but not LG increases the OCR of post natal OLs, under resting conditions (*** p < 0.001) and after the addition of FCCP (** p < 0.01) (B) NG and LG decrease OCR in resting conditions and in presence of mitotoxins in post natal OPCs compared to N1 conditions. (*** p < 0.001) (C) Neither NG or LG changes the ECAR of post natal OLs. (D) NG and LG reduce the ECAR of post natal OPCs compared to N1 conditions. (*** p < 0.001) (E) Post natal OLs increase their rate of ATP production under NG conditions (NG vs. N1, * p < 0.05) (F) NG and LG reduce the rate of ATP production in post natal OPCs compared to N1 conditions. (* p < 0.05, ** p < 0.01, *** p < 0.001) (G) Neither NG or LG changes ECAR in post natal OLs. (H) NG and LG reduce the ECAR in post natal OPCs compared to N1 conditions. (* p < 0.05, ** p < 0.01, *** p < 0.001).