Aberrant cGMP signaling persists during recovery in mice with oxygen-induced pulmonary hypertension
Fig 1
Hyperoxia exposure of neonatal mice is associated with persistent alveolar simplification.
Mice were exposed to hyperoxia or room air for 14d, followed by recovery in room air for an additional 7d (21d). (A) Mean alveolar area and (n = 7 animals per group). (B) chord length were measured using Scion software (n = 8 animals per group). (C) Representative hematoxylin-stained lung sections are shown for control 21d and hyperoxia + recovery 21d. Bar = 50 μm. Data are expressed as dot plots with each dot representing individual animals with means and SEM represented by horizontal lines. Results were analyzed using an unpaired t-test.