Systemic PD149163, a neurotensin receptor 1 agonist, decreases methamphetamine self-administration in DBA/2J mice without causing excessive sedation
Fig 3
PD149163 impairs voluntary locomotion in an open field beginning 10 minutes until at least 120 minutes following injection.
(A) Horizontal distance traveled during the 30-minute session in 5-minute bins beginning immediately following PD149163 injection. (B) PD149163 at both doses tested almost completely eliminated voluntary locomotion 90–120 minutes after injection.