The mechanism of monomer transfer between two structurally distinct PrP oligomers
Fig 9
Experimental investigation of the size invariance of .
A: asymmetric purification of O1 assemblies. The blue and red lines indicate purified portions of O1 peak corresponding to large and small assemblies, respectively. The depolymerisation of large O1 assemblies (in blue) and small O1 assemblies (in red) has been monitored at 0.3μM (B) and 6μM (C) and reveals an isokinetic behaviour between large and small O1 assemblies. This isokinetic behaviour suggests a kinetic parameter invariance all along the size distribution landscape and sheds light on the molecular basis of O1 architecture.