Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4
Fig 5
Cytokines upregulated by TLR4 signaling might play autocrine, paracrine and chemotactic roles.
Human monocytes differentiated by LPS, HMGB1 and nab-PXL were analyzed by RT-qPCR as described under Methods. Matched pairs of cytokines and receptors were grouped based on expression pattern suggestive of roles in (A, D, G) paracrine, (B, E, H) autocrine, or (C, F, I) chemotactic signaling pathways. Results are plotted as mean fold-change ± S.E.M in CD14+ cells treated with TLR4 ligands as compared with CSF1 alone.