Immunization of a wild koala population with a recombinant Chlamydia pecorum Major Outer Membrane Protein (MOMP) or Polymorphic Membrane Protein (PMP) based vaccine: New insights into immune response, protection and clearance
Fig 1
Systemic antibody responses post-vaccination with the 3MOMP and Pmp vaccines.
End point titre (EPT) of anti-MOMP and anti-PmpG IgGs in sera from pre-vaccination and 6 months post-vaccination koalas determined by ELISA. IgG titres against purified recombinant MOMP-F and MOMP-G proteins are shown for the 3MOMP vaccine for the whole cohort (panels A and C). For PmpG vaccine, recombinant purified PmpG protein was tested (panels E and F) with sera from PmpG vaccine koalas. Panels A, C, and E show a representation of the results as Log EPT for the whole 3MOMP vaccine or PmpG vaccine cohorts, pre- and 6 months post-vaccination (mean values are indicated). Panels B, D, F show the EPT values obtained for each koala in each vaccine cohort. MPV stands for Months Post-Vaccination. P values were calculated using Wilcoxon matched-pairs signed rank t-test are documented in the results section.