The IK1/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat
Fig 1
The preventative and curative effects of zacopride on MI- induced ventricular arrhythmias in anesthetized rats in vivo.
(A) Representative condensed ECGs (25 s/div). I, pretreatment; II, post-treatment; III, therapeutic treatment. (B) Time course of ECG traces for saline control rats (coronary occlusion + saline i.v.). Zac, zacopride, at 15 μg/kg. Lidoc, lidocaine, at 7.5 mg/kg.