Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo
Fig 1
Peripheral administration of KP-54 stimulates plasma LH levels in male mice more potently than KP-10.
(A) Bar graph showing the mean ± s.e.m. of LH levels in adult male mice 10 min and 2 hrs after intraperitoneal injection of PBS (veh, n = 8), 1 nmol KP-10 (n = 8), or 1 nmol KP-54 (n = 8). (B) Bar graph showing the mean ± s.e.m. of plasma LH levels 10 min and 2 hrs after intraperitoneal injection of PBS (n = 4), 1 nmol KP-10 (n = 5), 10 nmol (n = 4), 6 repeats of 1 nmol KP-10 every 10 min for 1h (n = 4), or 1 nmol KP-54 (n = 10). Letters indicate differences between groups at the p<0.05 significance level with higher P-values indicated (One-way ANOVA, followed by Tukey’s multiple comparison test was used to compare treatment groups).