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Inhibition of α_vβ₃ integrin induces loss of cell directionality of oral squamous carcinoma cells (OSCC)

Fig 4

DisBa-01 interacts specifically with integrin α_Vβ_3.

(A) Response of increasing concentrations of DisBa-01 interacting with the α_Vβ₃ integrin immobilized to the sensor chip. Starting at the time “0” and increasing its affinity as DisBa-01 concentration increases. (B) Response of increasing concentrations of DisBa-01 interacting with the α₅β₁. As the concentration of DisBa-01 increases, the affinity curves show very little displacement. (Single column- print in color)

doi: https://doi.org/10.1371/journal.pone.0176226.g004