Cloning retinoid and peroxisome proliferator-activated nuclear receptors of the Pacific oyster and in silico binding to environmental chemicals
Fig 3
Stereo view of ATRA bound to the ligand binding pocket of a CgRAR model.
Superimposition of model CgRAR (purple) on the crystal structure of HsRARγ LBD (green) bound to human RAR agonist ATRA. Original ATRA (grey) bound to HsRARγ LBD template (pdb ID: 2LBD); ATRA (light blue) to CgRAR wildtype, ATRA (dark blue) bound to mutated CgRAR. Divergent residues as well as arginines binding to the COOH group of ATRA including hydrogen bonds are indicated.