Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRγδ+ T cell large granular lymphocyte leukemia
Fig 2
Functional annotation of genes differentially expressed between TCRγδ+ T-LGL leukemia cases and healthy control TCRγδ+ T cell subsets.
(A) Comparison of TCRγδ+ T-LGL leukemia cases versus healthy control TemRA and (B) TemRO TCRγδ+ T cell subsets showing similar patterns with down-regulation of apoptosis and up-regulation of cancer-related processes. Sizing based on significance level (ANOVA), up- and down-regulation based on z-scoring. Plots were generated in QIAGEN’s Ingenuity Pathway Analysis.