Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRγδ+ T cell large granular lymphocyte leukemia
Fig 1
Unsupervised gene expression data analysis.
(A) Heatmap analysis shows clear correlations between TCRγδ+ T-LGL proliferation cases, and lower correlations to the healthy control TCRγδ+ T cell subsets, (B) the highest being to the TemRA TCRγδ+ T cell subset. (C) The clustergram shows that the TCRγδ+ T-LGL proliferation cases indeed form a distinct group, except for two cases which cluster closer to healthy control TemRA, TemRO and TCRVδ2 TCRγδ+ T cell subsets. (D) Principal component analysis (PCA) in three-dimensional (3D) graph shows similar clustering results. Thr = 0.7; 1336 probe sets. Case LGL058 indicated in italics was studied in duplo to assess reproducibility of the assay.