Integrated network analysis reveals potentially novel molecular mechanisms and therapeutic targets of refractory epilepsies
Fig 2
Refractory Epilepsies (RE) disease-gene network and relationships statistics.
(A) Disease-gene network showing the relationships of 1,086 genes corresponding to 23 MeSH Headings. The long label big nodes denote diseases in MeSH terminologies; the small nodes denote genes. The size of the node is positively related to the number of linked genes. Different colors represent different diseases. Genes located in the center of the network are associated with several diseases (e.g. SCN1A, KCNQ2). Genes located at the periphery of the network are associated with a single disease (e.g. CHRNA5, CHRNB4). (B) The gene-related MeSH heading numbers are distributed from 1 to 10, with different numbers for different colors. The total number of seed genes is 1086, of which 711 (accounting for 65.47%) are only associated with one disease subtype (MeSH heading).