Rapid tissue regeneration induced by intracellular ATP delivery—A preliminary mechanistic study
Fig 4
Comparison of the picrosirius red staining at days 4 and 15.
(A): The wound treated with ATP-vesicles shows a higher volume of collagen (bright red), while the control wounds have little collagen. The picrosirius red staining is viewed under circular polarized light. Increased type I (orange) and type III collagen (green) content is seen in ATP-vesicle-treated wounds as healing progresses. The control wounds have much less collagen expression. The collagen fibers also increase in size and mature at a faster rate in ATP-vesicle-treated wounds when compared with the controls (Scale bar is 100 μm). (B). Graphical representation of morphometrically measured area represented by collagen type 1 among the three groups.