Abnormal repression of SHP-1, SHP-2 and SOCS-1 transcription sustains the activation of the JAK/STAT3 pathway and the progression of the disease in multiple myeloma
Fig 3
SHP-1 and SHP-2 gene expression inversely correlate with the level of bone marrow infiltration.
(A) Correlation between bone marrow infiltration and the relative gene expression of SHP-1, SHP-2 and SOCS-1 in the sorted bone marrow plasma cells. Spearman rank correlation (r) and p values are indicated. (B) The degree of bone marrow infiltration is compared in patients exhibiting normal or decreased expression of SHP-1, SHP-2 and SOCS-1 genes. P values are indicated.