A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype F subtypes
Fig 4
Protection of mice from BoNT/F subtypes challenged by HBAT or triple mAb combination.
(A) Mouse survival following intoxication with different toxin subtypes. The combination of 6F5.1/6F11/6F13 (3Ab) rescued mice at much lower dosage (the solid lines) than the equine-derived HBAT showing with dash line. (B) Neutralizing capacity of HBAT and triple mAb combination (LD50/μg), calculating by toxin amount (LD50) divided by HBAT or mAbs dosage (μg) that rescue >70% of mice.