A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype F subtypes
Fig 1
Comparison of the BoNT/F subtypes.
The BoNT/F1 model was constructed by merging the BoNT/F1 LC crystal structure (pdb ID: 2A97) and a model of the BoNT/F1 LC-HN model based on the BoNT/A1 crystal structure (pdb ID: 2NZ9). BoNT/F subtypes were compared to the BoNT/F1 by using the tool MultAlin [31] and were visualized using ESPript 3 [32]. The physiochemical similarity of amino acids is indicated on a color scale from white to red. The white indicates 100% identity and the red indicates 0% physiochemical similarity.