Mangiferin protects against adverse skeletal muscle changes and enhances muscle oxidative capacity in obese rats
Fig 4
Effect of mangiferin treatment on muscle fiber-type composition, and predicted muscle maximal shortening velocity (Vmax) and the muscle force-velocity relationship in obese rats.
The percentages of myosin-based fiber-types (A, B), and predicted Vmax (C) and force-velocity curves (D), dereived according to the Hill-type mathematical model (inset) [42], were determined in Zucker rats with the lean (Fa/Fa or Fa/fa) phenotype (Lean), and Zucker rats with the obese (fa/fa) phenotype that were treated with either placebo (Obese Placebo) or 15 mg/kg BW/day of Mangiferin for 8 weeks (Obese Mangiferin). Bars show means ± SD, n = 20 rats/group. * P < 0.05 vs Lean, # P < 0.05 vs Obese Placebo (one-way ANOVA with Fisher LSD post-hoc test). Data in D are expressed as means of 20 rats/group. V, shortening velocity; Vmax, maximal shortening velocity; P, isometric tension; P0, maximal isometric tension.