Multi-scale model of drug induced adaptive resistance of Gram-negative bacteria to polymyxin B
Fig 5
Simulated density distributions of KD at various times for KP619 bacteria population exposed to polymyxin B concentration of C = 8 mg/L.
Si The vertical line indicates KDcrit = 6003 nM. The ranges of y axes were adjusted to best illustrate the shape of distribution. At t = 0 the distribution is equal to the initial density n0(KD) described by the Weibull distribution Eq (16). As time progresses the density of cells with KD < KDcrit vanishes whereas cells with KD > KDcrit form a new population that eventually grows exponentially. The density distribution at KD = KDcrit remains constant.