Interpretation of metabolic memory phenomenon using a physiological systems model: What drives oxidative stress following glucose normalization?
Fig 2
Model quality in reproducing data.
(A) Observations vs. population model predictions. (B) Observations vs. individual model predictions. The straight line represents a perfect agreement between experimental and calculated values. The magnitude of glucose exposure is coded by color; the type of experiment is coded by dot shape. (C) Population simulations of ROS dynamics in CG experiments. (D) Population simulations of ROS dynamics in OG experiments. Solid line denotes model-predicted median; gray shades correspond to different percentiles of population predictions; the magnitude of glucose exposure is coded by color; the type of experiment is coded by dot shape.