A multi-objective constraint-based approach for modeling genome-scale microbial ecosystems
Fig 2
Illustration of microbial ecosystem CBM.
For the sake of illustration, an ecosystem may be considered to comprise three microbial strains. (A) According to the metabolic model, each microorganism is considered a separate compartment, depicted here in green, orange, and purple. Metabolic networks are linked via an additional compartment, termed the “pool” (blue)), which sums up all external metabolites exchanged between organisms and the environment. (B) depicts the Stoichiometric Matrix Sσ, where each compartment is colored accordingly, with their corresponding ς and ξ submatrices. (C) Pareto front. When performing an FBA for multiple organisms, a set of points known as the Pareto front (in yellow) is obtained. Objective functions f1, f2 and f3 define the “objective space”.